Identification of Two New Cholesterol Interaction Sites on the A2A Adenosine Receptor
نویسندگان
چکیده
منابع مشابه
Predictions for cholesterol interaction sites on the A2A adenosine receptor.
Molecular dynamics simulations of the A(2A) adenosine receptor totaling 1.4 μs show clear evidence for specific sites mediating interactions between adenosine-bound A(2A) and cholesterol. The strongest evidence is for three binding sites. Two are in the extracellular leaflet, with one site interacting with helices VII and I, and the other with helices II and III. One site is located in the intr...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2017
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2017.09.027